Steroids and modern immunosuppression.

Steroids and modern immunosuppression.

Modern Immunosuppression Regimens in Kidney Transplantation

The initial results of kidney transplantation were significantly affected by a high rate of acute rejection as well as significant perioperative morbidity. Historically, the armamentarium of the transplant physician consisted of glucocorticoids and azathioprine. Significant improvements in the science and understanding of kidney transplantation immunology have lead to the development of inducti...

Some modern mass spectrometric methods for steroids and terpenoids.

Introduction Mass spectrometry has been applied to isoprenoid molecules for many years, resulting in well established analytical procedures such as combined gas chromatography-mass spectrometry (Rose & Johnstone, 1982; Rose, 1983). Such methods are not discussed here. Obviously, this does not reflect their value: g.c.-m.s. is an excellent tool for detection, identification and quantification of...

Immunosuppression for pediatric cardiac transplantation in the modern era.

With the advent of the T cell activation inhibitors such as cyclosporine, heart transplant success rates for pediatric patients have improved to the point that the initially restricted ages and indications have expanded considerably. Currently the half-life (50% still alive) for children transplanted in the early 1980s is approximately 12-14 years. Decades-long survival seems likely. Components...

Hepatitis C and renal transplantation in the era of modern immunosuppression.

Kidneys from donors who are positive for hepatitis C virus (DHCV+) have recently been identified as an independent risk factor for mortality after renal transplantation. However, it has not been determined whether risk persists after adjustment for baseline cardiac comorbidity or applies in the era of modern immunosuppression. Therefore, a historical cohort study was conducted of US adult cadav...